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Crohn Disease, anxiety and psychedelics

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Hey DoctorX

I have a ‘friend’ whom whilst tripping on 25I-Nbome started to come down and freaked out a bit.

My friend now suffers from anxiety and I don’t know what to do about it, and would have to see a psycologist to get a prescription to get meds

This person suffers from crohn’s disese and i’m worried that could have been a part of the problem.

Would there be any risk of them taking xanax to stop the anxiety attacks?EDIT: Friend is around the age of 18 and female. Very short and skinny

Originally posted in SR 2.0 20/4/14 . Reviewed 8/2/23

Xanax (alprazolam) or any other short half-life benzodiazepine may be an option to resolve a panic attack in an acute situation, and the fact that your friend suffers from Crohn’s disease is not relevant in this regard.

However, there are some additional considerations. You must be absolutely sure that your friend’s problem is indeed a «panic attack». The effects and risks of 25i_NBOMe are unpredictable and, in case of doubt, a medical evaluation is recommended to rule out possible serious organic complications.

The duration of the alleged «panic attack» is important in this regard as it does not seem a likely diagnosis if the symptoms last more than a few hours.

I do not believe that there is a direct link between psychedelics and Crohn’s disease, although it is true that anxiety disorders are more frequent in these patients.

Benzodiazepines such as alprazolam should never be used as the sole long-term pharmacological treatment for anxiety disorders. There are much safer and more effective pharmacological options.

MDMA / LSD and sildenafil combination

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Is it safe having sildenafil with lsd or mdma in combination?

Originally posted in SR 2.0 16/4/14. Reviewed 9/2/23

There are no reported cases of severe toxicity mixing MDMA or LSD and sildelnafil. The combination is probably safe from a pharmacological point of view.

The risk of problems or adverse effects depends on dosage, timing, previous experience with both substances and personal characteristics. Some common effects of sildenafil (headache, nasal congestion) could be enhanced by psychedelic effects.

Let’s just say that when it comes to exploring the depths of sexuality and substances , it’s all about finding the right dose. 

The psychedelic effects of low to moderate doses of LSD can offer a unique perspective on sex that some people may find interesting. Too much LSD and you’ll be absorbed by a fractal  kaleidoscope of colors, completely forgetting about any naughty intention.

Something similar (though less intense) happens with MDMA. Low to medium doses can intensify and modify the qualities of sex, and a moderate dose of sildenafil can help a man maintain an erection (if that is what is intended). Increasing the dose is more likely to result in deep conversation, cuddling and cuddling (which isn’t bad either). In the latter case, sildenafil is likely to be ineffective and have mostly adverse effects.

In any case, the most dangerous combination is between PDE-5 inhibitors (Viagra, Cialis, Levitra…) and poppers. Both substances causes rapid blood flow and risks of  low blood pressure and fainting are common. In rare cases or persons with previous cardiological diseases it is possible to suffer more severe problems (heart attack, arrythmias…)

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DMT and 25I-NBOMe interactions with psychiatric drugs

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DoctorX, I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I’m wondering how these will affect drug use.

I’ve been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I’ve also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I’m on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E? Thanks in advance for any advice.

Originally posted in SR 2.0 16/4/14 . Reviewed 7/2/23

Both antipsychotics (Abilify, aripiprazol) and antideppressants (Cymbalta, duloxetine) diminish effects psychedelics. To my knowledge there are no studies involving 2C-x family but according to pharmacology and communications of users, this effect is foreseable. 

Some people try to counteract this effect increasing the psychedelic dosage. I in a practical point of view this is not recommended at all.

First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics.  

Ketamine and paracetamol interaction

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Hi Doc, Doing ketamine after taking Paracetamol and/or Ibuprofen (recommended dosage)…Is it particularly dangerous? Can’t imagine it’s great for the liver? Not something to make a habit of but the ketamine distracts from the pain.
Many thanks.

Originally posted in SR 2.0 4/4/14 . Reviewed 5/2/23

Based on current knowledge, there are no documented adverse interactions between recommended dosages of paracetamol or ibuprofen and ketamine. It can be concluded that the combination of these medications is considered to be safe

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Hyperthyroidism and drugs

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I’ve posted a couple times about rapid heart palpitations I’ve been getting recently. I don’t believe it’s drug related, all I’ve been doing is LSD, psilocybin and DMT.

I had been taking Adderall but cut it out when this started.I got into a free clinic and was told my problem could be hyperthyroid. That also happens to run in my family (my mother had to get the radioactive iodine treatment to kill hers).

They said my thyroid was slightly englarged (no nodules though) and I HAVE been feeling a slight tightness in my neck right over the gland (didn’t even put it together until I was at the docs office).All they did was give me a beta blocker and ask me to come back in a month. The beta blocker IS slowing my heart and lowering my BP, but it’s only addressing a symptom and not the problem, right?I know there’s no sure fire cure for hyperthyroid issues, but do you have any experience/suggestions on how to control it? I’d rather not take thyroid suppressing chems and definitely don’t want to nuke my damn thyroid.I’ve heard that bugleweed and motherwort can help lower thyroid function over time. Is there anything dietary I should/shouldnt be doing? I’ve also heard it can be due to low/high iodine levels but I wouldn’t want to start meddling with that without knowing wether my iodine is high or low.

Could applied kinesiology give me a clue? Do you even believe in that and should I?I’m staying away from all stims, be it caffiene, decongestants or uppers. I’m still using psychedelics about 1x per week and the rapid heart beat is of course more noticable and worrying while in that state. It’s becoming a real bummer on my life and my trips!Again, I don’t expect conclusive answers but anything you have to offer on hyperthyroidism is greatly appreciated!

Originally posted in SR 11/3/14 .Reviewed 6/2/13

The type of treatment that is best for you depends on factors such as your age, sex, the cause of your hyperthyroidism, the amount of thyroid hormone produced by your body, and any other medical conditions you may have.

In general, antithyroid drugs, radioactive iodine, and surgery are considered to be the most effective options. Sometimes, treatment for hyperthyroidism can lead to hypothyroidism, requiring daily hormone replacement therapy via oral administration.

However, this is not a major concern for most people and has fewer risks and complications compared to uncontrolled hyperthyroidism. The effectiveness of natural herbs or supplements is unknown.

I would advise against the use of psychedelics for your specific condition, at least until your diagnosis is clearly established. Use of ketamine is particularly contraindicated in this condition.

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