DMT dosis, efectos y riesgos

DMT dosis,efectos y riesgos 

Quiero probar el DMT por primera vez y quería preguntarle  cuáles son las dosis, los efectos y los riesgos del DMT. ¿Qué tipo de DMT debo utilizar (DMT o derivados)?

Publicado originalmente en SR 2.0 23/10/2013. Revisado el 20/2/22


La DMT (dimetiltriptamina) es una potente sustancia psicodélica conocida por sus profundos efectos visuales y psicodélicos.La DMT se encuentra en una variedad de plantas y también se ha detectado en pequeñas cantidades en el cuerpo humano, aunque su función sigue siendo un misterio.

Esta sustancia puede extraerse de fuentes naturales o sintetizarse químicamente, lo que permite una mayor precisión en la dosificación. La presencia de DMT en plantas ( Mimosa hostilis, Psychotria viridis, Anadenanthera peregrina… ). y la ha sido aprovechada en preparaciones tradicionales como la ayahuasca, consumida en ceremonias espirituales por varios pueblos indígenas sudamericanos.

Sin embargo, es importante tener en cuenta que el DMT no es activo por vía oral a menos que se combine con otro fármaco, como un inhibidor de la monoaminooxidasa.

Por tanto, las rutas del DMT son:

Fumar es la vía de administración más común y segura.

Esnifar o inyectar

La dosis típica de DMT es de entre 15 y 60 miligramos. Fumar cristales de DMT purificado proporciona una experiencia intensa pero breve, que suele durar entre 5 a 15 minutos. Las experiencias pueden variar significativamente, con algunas personas reportando encuentros con entidades, viajes a dimensiones aparentemente otras, o profundos insights personales.Por lo tanto, los usuarios suelen inhalar sucesivas inhalaciones de humo hasta que ya no pueden o no quieren dar otra calada. Sin embargo, es importante tener en cuenta que fumar DMT solo es peligroso y no se recomienda. Para evitar accidentes lo mejor es tener presente un acompañante de confianza.

Una de las particularidades del DMT es que puede sintetizarse en un laboratorio o aparecer de forma natural en determinadas plantas, como las utilizadas en la ayahuasca  El DMT sintético es ventajoso porque facilita la medición precisa de la dosis.

Además, existen diferentes derivados de DMT con diferentes propiedades. Por ejemplo, el 5-MeO-DMT tiene efectos similares al DMT pero es mucho más potente. Una dosis de sólo 5 a 10 miligramos fumadas es suficiente para experimentar todos los efectos. El 4-AcO-DMT, por otro lado, es un derivado del DMT activo por vía oral y tiene una duración de 3-5 horas.

Sin embargo, existen riesgos asociados con el uso de DMT. El estrés psicológico puede ocurrir en personas que no pueden integrar la experiencia. También aquellos con problemas de salud mental subyacentes, particularmente aquellos con una predisposición genética, pueden experimentar reacciones psicóticas.

El miedo también puede ser un factor y existe riesgo de accidentes, como dejar caer una tubería o derribar cosas. Por estas razones, es importante abordar el uso de DMT con precaución y asegurarse de estar preparado mental y físicamente para la experiencia.

DMT dosage, effects and risks

DMT dosage, effects and risks 

I want to try DMT and wanted to ask you as a first timer which are the DMT dosage, effects and risks.   What type of DMT should i use (DMT or derivatives) ?

Originally posted in SR 2.0 23/10/2013. Reviewed 20/2/22


DMT ( dimethyltryptamine) is a potent psychedelic substance known for its profound visual and psychedelic effects. However, it is important to note that DMT is not active  orally unless it is combined with another drug, such as a monoamine oxidase inhibitor. Therefore, routes for DMT are smoking, injecting or snorting . Of these options, smoking is the most common and safest route of administration.

The typical dosage for DMT is between 15 and 60 milligrams. So users typically take successive breaths of the smoke until they are no longer able or willing to take another hit. However, it is important to note that smoking DMT alone is dangerous and not recommended. To avoid accidents, it is best to have a trusted companion present.

One of the unique aspects of DMT is that it can be synthesized in a laboratory or appears naturally in certain plants, such as those used in ayahuasca (Mimosa hostilis, Psychotria viridis, Anadenanthera peregrina…) . Synthetic DMT is advantageous because it makes it easier to measure the dosage accurately.

Additionally, there are different derivatives of DMT with varying properties. For example, 5-MeO-DMT is similar in effects to DMT but is much more potent. A dose of just 5-10 milligrams smoked is enough to experience the full effects. 4-AcO-DMT, on the other hand, is a derivative of DMT active by oral route and lasts for 3-5 hours.

However, there are risks associated with using DMT. Psychological stress can occur in individuals who are unable to integrate the experience. Also in those with underlying mental health issues, particularly those with a genetic predisposition, may experience psychotic reactions.

Fear can also be a factor, and there is a risk of accidents such as dropping a pipe or knocking things over. For these reasons, it is important to approach DMT use with caution and to ensure that one is mentally and physically prepared for the experience.


Antidepressants and psychedelic interactions

Is it safe to combine psychedelics and antidepressants?

I’m on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I’m not on antipsychotics for anything like bipolar disorder or schizophrenia So, correct me if I’m wrong, but I feel like it is safe for me to use psychedelics.I have one more question. On the part about counteracting the effects of the medication by increasing psychedelic dosage, is this safe to do with DMT? Also, is there any cross tolerance between 2C-X, NBOMe series, and DMT?

Originally posted in SR 2.0 . Reviewed 3/3/23

It depends on what we mean by «safe». The pharmacological combination of the prescription drug you refer to (probably an SSRI) and DMT or 2C-X is unlikely to produce acute or permanent organ damage. On a psychological level, however, psychedelics always have an unpredictable nuance.

Experiences of anxiety or depression afterwards are likely to be more frequent, not so much because of the combination of drugs but because of your state of mind.

The risks of 25x-NBOMe are potentially much higher. Cases of seizures, hyperthermia and renal failure are relatively frequent and human research is nil compared to DMT and 2C-X. So, their use is strongly discouraged.

Isotretinoin and recreational drugs

If I take Isotretinoin, it’s safe to use LSD, Psylocibin, DMT, weed and alchool?
How often is to often to take LSD and DMT? What are harms of DMT?

Originally posted in SR 2.0 . Reviewed 20/2/22

Isotretinoin is a drug used in the treatment of some types of acne. Alcohol is the only drug strictly contraindicated with isotretinoin because of its toxic effect on the liver. All other substances listed are pharmacologically safe in combination with isotretinoin.

Some indirect data suggest that psilocybe mushrooms may also slightly increase the risk of liver problems in combination with isotretinoin. But in practice, no toxicity cases are reported, and this combination is probably safe.

Taking psychedelics is like going to Disneyworld (if you like Disney characters, of course). The first few times are extraordinary, but you will get tired and bored if you go too often. The frequency (in both cases) depends on personal preference. For some people, it’s twice a year. For others, once a month, but most people find it boring to do it every weekend. Generally, the less frequent the use, the greater the likelihood of enjoying the experience.

DMT, like other classic psychedelics, produces no effects. Harm is related to mental problems (anxiety, difficulty integrating the experience) or, very rarely, persistent mental health problems.


DMT and 25I-NBOMe interactions with psychiatric drugs

DoctorX, I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I’m wondering how these will affect drug use.

I’ve been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I’ve also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I’m on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E? Thanks in advance for any advice.

Originally posted in SR 2.0 16/4/14 . Reviewed 7/2/23

Both antipsychotics (Abilify, aripiprazol) and antideppressants (Cymbalta, duloxetine) diminish effects psychedelics. To my knowledge there are no studies involving 2C-x family but according to pharmacology and communications of users, this effect is foreseable. 

Some people try to counteract this effect increasing the psychedelic dosage. I in a practical point of view this is not recommended at all.

First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics.