Seizures after using 25-I-NBOMe

Is it possible to suffer seizures after using 25-I-NBOMe ?

A friend of mine bought some of these blotters. And he has suffered this problem (epileptic seizures) in at least two different occasions. But this is strange as he is not epileptic. However, he has experience with other psychedelics as LSD or mushrooms.  Can you provide any advice, dear DoctorX? 

Originally posted in SR 2.0 . Reviewed 20/2/22

Classical drugs, such as heroin, cocaine, and cannabis, are safer than New Psychoactive Substances (NPS) due to extensive research on their effects and risks. But NPS use untested chemical compounds, which can result in unpredictable and potentially dangerous effects. Additionally, the chemical composition of NPS can be easily altered to evade legal regulations, making it challenging to determine their potential health effects.

You can find thousands of studies about LSD. NBOMEs have only been tested in brain pig receptors. So, there is no experience with them in human use.

There are many cases of severe toxicity and death related to NBOMe and reported in recent years. However, the physical toxicity of LSD is non-existent.

Typical (and frequent) effects of 25-X-NBOMe are:

  • Overdose: NBOMEs is extremely potent, and even small amounts can cause an overdose. Symptoms of overdose can include seizures, cardiac arrest, and death.
  • Psychiatric effects: NBOMEs can cause intense and unpredictable psychiatric effects, including anxiety, paranoia, and psychosis. These effects can last for days or even weeks after use.
  • Physical effects: NBOMEs can cause a range of physical effects, including increased heart rate and blood pressure, nausea, vomiting, and seizures.

NBOMEs can lead to seizures in overdose, there are some reports about this in the last years:

In this post we discussed how to rule out some LSD adulterants with an UV-lamp


Antidepressants and psychedelic interactions

Is it safe to combine psychedelics and antidepressants?

I’m on the medication for depression and anxiety, which certain psychedelic drugs seem to help a little bit. I’m not on antipsychotics for anything like bipolar disorder or schizophrenia So, correct me if I’m wrong, but I feel like it is safe for me to use psychedelics.I have one more question. On the part about counteracting the effects of the medication by increasing psychedelic dosage, is this safe to do with DMT? Also, is there any cross tolerance between 2C-X, NBOMe series, and DMT?

Originally posted in SR 2.0 . Reviewed 3/3/23

It depends on what we mean by «safe». The pharmacological combination of the prescription drug you refer to (probably an SSRI) and DMT or 2C-X is unlikely to produce acute or permanent organ damage. On a psychological level, however, psychedelics always have an unpredictable nuance.

Experiences of anxiety or depression afterwards are likely to be more frequent, not so much because of the combination of drugs but because of your state of mind.

The risks of 25x-NBOMe are potentially much higher. Cases of seizures, hyperthermia and renal failure are relatively frequent and human research is nil compared to DMT and 2C-X. So, their use is strongly discouraged.

Crohn Disease, anxiety and psychedelics

Hey DoctorX

I have a ‘friend’ whom whilst tripping on 25I-Nbome started to come down and freaked out a bit.

My friend now suffers from anxiety and I don’t know what to do about it, and would have to see a psycologist to get a prescription to get meds

This person suffers from crohn’s disese and i’m worried that could have been a part of the problem.

Would there be any risk of them taking xanax to stop the anxiety attacks?EDIT: Friend is around the age of 18 and female. Very short and skinny

Originally posted in SR 2.0 20/4/14 . Reviewed 8/2/23

Xanax (alprazolam) or any other short half-life benzodiazepine may be an option to resolve a panic attack in an acute situation, and the fact that your friend suffers from Crohn’s disease is not relevant in this regard.

However, there are some additional considerations. You must be absolutely sure that your friend’s problem is indeed a «panic attack». The effects and risks of 25i_NBOMe are unpredictable and, in case of doubt, a medical evaluation is recommended to rule out possible serious organic complications.

The duration of the alleged «panic attack» is important in this regard as it does not seem a likely diagnosis if the symptoms last more than a few hours.

I do not believe that there is a direct link between psychedelics and Crohn’s disease, although it is true that anxiety disorders are more frequent in these patients.

Benzodiazepines such as alprazolam should never be used as the sole long-term pharmacological treatment for anxiety disorders. There are much safer and more effective pharmacological options.

DMT and 25I-NBOMe interactions with psychiatric drugs

DoctorX, I am currently taking abilify (not sure on the dose, maybe ~5mg), Wellbutrin (I think 75mg), and cymbalta (60mv morning, 30mg at night) and I’m wondering how these will affect drug use.

I’ve been experimenting with DMT and 25i-NBOMe and have noticed reduced effects and reduced visuals. I’ve also noticed with 25i I need to take larger doses (~4-5mg) to feel some effects with limited visual effects. I also plan on trying 2-CE soon.

So my question is, are these diminished effects normal for someone taking the medication that I’m on? How can I get more pronounced effects effects from these drugs while on my medications? What should I do in terms of safety and dose regarding these drugs, specifically the 2C-E? And what dose should I take for the 2C-E? Thanks in advance for any advice.

Originally posted in SR 2.0 16/4/14 . Reviewed 7/2/23

Both antipsychotics (Abilify, aripiprazol) and antideppressants (Cymbalta, duloxetine) diminish effects psychedelics. To my knowledge there are no studies involving 2C-x family but according to pharmacology and communications of users, this effect is foreseable. 

Some people try to counteract this effect increasing the psychedelic dosage. I in a practical point of view this is not recommended at all.

First, because it will increase physical adverse effects from psychedelics and risk of intoxication (this is particularly important in 2C-x and 25-x-NBOMEs). Second, because it will increase the risks of bad psychedelic experiences. And this is particularly important if you are using psychiatric medication. This last question is not only about pharmacological interactions, but also about the cause you are using medication. It is probable that this cause (the reason that makes that you need to use this medication) makes not recommendable to use psychedelics.