5-MeO-DMT risks

Which are 5-MeO-DMT risks?

I am very interested in exploring entheogens. But I am concerned about 5-MeO-DMT risks.  I am apprehensive about whether there are any dangers . I have never read about deaths or serious complications.

But the many trip reports mention breathing irregularities, having to remember to breath, people turning a bit blue in the face, extremely elevated heart rate or blood pressure, feeling like an elephant in sitting on you…

I read the LD50 is very high though, far higher than the active dose. So my question, are these physical effects all in peoples’ heads? Is 5-MEO-DMT just as safe as N-N-DMT or are there any real dangers involved?

Originally posted in SR 2.0 . Reviewed 20/2/22

Effects and risks of 5-MeO-DMT have been studied during decades. In fact, 5-MeO-DMT is a common constituent of many different plants and has been used traditionally in psychoactives snuffs. Examples are  Yopo (Anadenanthera colubrina seeds), Epena from Virola spp, and some ayahuasca-type brews. Risks are basically psychological. As many other classical psychedelics, physical toxicity is  very low. 5-MeO-DMT can cause intense and overwhelming psychedelic experiences, which may lead to anxiety, panic attacks, and paranoia.

Short term (1-10 minute) non-responsiveness or unconsciousness can appear with smoked doses over 8-10 mg or insufflated doses over 15-20 mg. So sitting down and have a person that can take care of you are extremely important. The drug can cause physical symptoms such as increased heart rate, elevated blood pressure, dizziness, and nausea.

I think breathing problems are probably related to psychological stress. There are no cases in science of organic toxicity associated to 5-MeO-DMT

It is importantto avoid using 5-MeO-DMT in combination with other substances. Specially those that affect serotonin levels in the brain, such as antidepressants, SSRIs, and MAOIs.

This is because combining 5-MeO-DMT with these substances (particularly MAOIs) could potentially result in serotonin syndrome. This is a a potentially life-threatening condition characterized by high levels of serotonin in the body. Additionally, the use of stimulants such as amphetamines and cocaine may increase the risk of adverse effects associated with 5-MeO-DMT. This includes hypertension and tachycardia.


DMT dosage, effects and risks

DMT dosage, effects and risks 

I want to try DMT and wanted to ask you as a first timer which are the DMT dosage, effects and risks.   What type of DMT should i use (DMT or derivatives) ?

Originally posted in SR 2.0 23/10/2013. Reviewed 20/2/22


DMT ( dimethyltryptamine) is a potent psychedelic substance known for its profound visual and psychedelic effects. However, it is important to note that DMT is not active  orally unless it is combined with another drug, such as a monoamine oxidase inhibitor. Therefore, routes for DMT are smoking, injecting or snorting . Of these options, smoking is the most common and safest route of administration.

The typical dosage for DMT is between 15 and 60 milligrams. So users typically take successive breaths of the smoke until they are no longer able or willing to take another hit. However, it is important to note that smoking DMT alone is dangerous and not recommended. To avoid accidents, it is best to have a trusted companion present.

One of the unique aspects of DMT is that it can be synthesized in a laboratory or appears naturally in certain plants, such as those used in ayahuasca (Mimosa hostilis, Psychotria viridis, Anadenanthera peregrina…) . Synthetic DMT is advantageous because it makes it easier to measure the dosage accurately.

Additionally, there are different derivatives of DMT with varying properties. For example, 5-MeO-DMT is similar in effects to DMT but is much more potent. A dose of just 5-10 milligrams smoked is enough to experience the full effects. 4-AcO-DMT, on the other hand, is a derivative of DMT active by oral route and lasts for 3-5 hours.

However, there are risks associated with using DMT. Psychological stress can occur in individuals who are unable to integrate the experience. Also in those with underlying mental health issues, particularly those with a genetic predisposition, may experience psychotic reactions.

Fear can also be a factor, and there is a risk of accidents such as dropping a pipe or knocking things over. For these reasons, it is important to approach DMT use with caution and to ensure that one is mentally and physically prepared for the experience.