DMT ( dimethyltryptamine) is a potent psychedelic substance known for its profound visual and psychedelic effects. However, it is important to note that DMT is not active  orally unless it is combined with another drug, such as a monoamine oxidase inhibitor. Therefore, routes for DMT are smoking, injecting or snorting . Of these options, smoking is the most common and safest route of administration.

The typical dosage for DMT is between 15 and 60 milligrams. So users typically take successive breaths of the smoke until they are no longer able or willing to take another hit. However, it is important to note that smoking DMT alone is dangerous and not recommended. To avoid accidents, it is best to have a trusted companion present.

One of the unique aspects of DMT is that it can be synthesized in a laboratory or appears naturally in certain plants, such as those used in ayahuasca (Mimosa hostilis, Psychotria viridis, Anadenanthera peregrina…) . Synthetic DMT is advantageous because it makes it easier to measure the dosage accurately.

Additionally, there are different derivatives of DMT with varying properties. For example, 5-MeO-DMT is similar in effects to DMT but is much more potent. A dose of just 5-10 milligrams smoked is enough to experience the full effects. 4-AcO-DMT, on the other hand, is a derivative of DMT active by oral route and lasts for 3-5 hours.

However, there are risks associated with using DMT. Psychological stress can occur in individuals who are unable to integrate the experience. Also in those with underlying mental health issues, particularly those with a genetic predisposition, may experience psychotic reactions.

Fear can also be a factor, and there is a risk of accidents such as dropping a pipe or knocking things over. For these reasons, it is important to approach DMT use with caution and to ensure that one is mentally and physically prepared for the experience.