It is important to understand that drugs cannot be classified as solely good or bad; their effects depend on the manner in which they are used.
It is a myth that drugs can burn holes in the brain as substances such as hydrochloric acid are not considered drugs.
MDMA, on the other hand, has undergone four decades of intensive research in both humans and animals, making it much safer than the psychedelic phenylethylamines. MDMA has been tested on thousands of people in clinical trials, whereas the human pharmacology of 2C-B or 2C-E has only been documented in anecdotal studies.
The use of phenylethylamines from the 2C family is uncommon at the population level. However, while the use of some members such as 2C-I, 2C-B, and 2C-E has gone unnoticed for decades, cases of toxicity and serious adverse effects from newer ones such as 2C-B Fly and Bromodragonfly have been reported more frequently. In addition to the lack of human experience, many psychedelic phenylethylamines are highly potent, and small differences in dosage, sometimes measured in milligrams or even micrograms, can produce intense effects, including organ toxicity.
It is true that the aftermath or «comedown» related to MDMA use is harder for most people than with 2C-X. This is due to both the pharmacological properties of each substance and the dose, frequency, and patterns of use.