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LSD tolerance and microdosing

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LSD tolerance and microdosing

Hello, I have a question about LSD tolerance and microdosing. Yes.  I know is unknown territory but please let me know if this is a wrong line of thought.

Average trip 200ug needs at least 14 days for you to restore tolerance. But with less amount wouldn’t you also need less time for that?

So if I take 10ug that’s 5% then I would need only 5% of the restoring time, that is 0.75 days. According to this logic only 1 day after that dosage will be more than plenty to recuperate and don’t build tolerance.

And if you take even lower amount, let’s say 5ug or 2.5% that’s 0.375 days of recovery time. So if you take it at the morning, for example 8:00 AM, next morning at the same hour you will be more than recovered. So you could take 5ug all week?. This will require testing and I guess is variable to each individual.

I’m very interested in this and help is much appreciated.

Originally posted in SR 2.0 13/10/2013. Reviewed 20/2/22

To develop tolerance to LSD, a minimum dosage and frequency of administration are necessary. Tolerance depends on the chemical characteristics and metabolism of each drug. Also, to develop tolerance it is neccesary a minimun dosage and frequency of administration.

Minimum psychoactive dosage of LSD is 25 μg (micrograms, 1/1000 mg). Most people achieve full psychedelic effects with 100-200 μg.

Tolerance to LSD develops quickly (for most people it is very difficult to use LSD 2 or 3 consecutive days) and also disappears quickly. Studies show that tolerance dissapears tipically 4 days after last administration

Although reducing dosages theoretically reduces tolerance time, dosages lower than 20-30 mg have virtually no psychological effects. And daily administration of very low dosages could still affect tolerance development neurochemically.

The linear relationship between dose and tolerance is likely true within the full dose range of 75-200 μg. But this is less clear at lower doses.

The problem with microdoses is the lack of established guidelines and appropriate doses. According to different surveys, microdose users take between 5 and 20 mg. Some people do it daily, others twice a week, and others once a week.

However, there are not enough clinical trials to determine the most appropriate regimen that does not produce tolerance or psychedelic effects.

It is also unclear what the exact effect of microdoses is and which group of patients or healthy individuals can benefit from this use.

Given that this is a highly active field of research, more exact data is likely to emerge in the near future.

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LSD, MDMA and infliximab interactions

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Hello I was wondering if you knew anything about tnf-alpha remicade(infliximab). I like to know if it is there are LSD, MDMA and infliximab interactions, dangerous for a person using this drug for IBD.

Originally posted in SR 2.0 . Reviewed 20/2/22

Infliximab is one of the most recent treatments available in inflamatory bowel disease (IBD, inflammatory bowel disease: Crohn’s Disease /Ulcerative Colitis). 

Infliximab is sometimes used intravenously in severe disease flares. In these circumstances the use of recreational drugs or psychedelics is contraindicated. The patient is usually hospitalized and in poor general condition. So he will not probably find psychedelics enjoyable. 

But, on other occasions it is used periodically subcutaneously. If the patient’s general condition (both physical and psychological) is acceptable, there are no data to assume that MDMA or LSD increase the risk significantly. An increase in adverse, toxic or toxic effects is not to be expected.

 

 

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LSD microdosing

DoctorXFiles

I have read about LSD microdosing. What is the right dosage and frequency? Does it have real health benefits?

Originally posted in The Hub 15/5/17 . Reviewed 20/2/22

LSD microdosing refers to taking small, sub-perceptual doses of the psychedelic drug LSD (Lysergic acid diethylamide). The idea behind microdosing is to experience the potential benefits of LSD, such as increased creativity, focus, and productivity. But also avoid the intense psychedelic effects associated with a typical recreational dose.

So, a microdose of LSD typically ranges from around 5 to 20 micrograms, generally around 10-20% of a recreational dose. Microdosing is used on a schedule, with individuals taking a small amount every few days.

In fact, the effects of LSD microdosing are still a subject of research. But some anecdotal evidence suggests that it can lead to improvements in mood, focus, creativity, and social interactions. However, it’s important to note that LSD is still a powerful drug. Even at low doses, it can have side effects such as anxiety, paranoia, and changes in perception.

Anecdotal evidence suggests that LSD microdose may improve mood, creativity and social interactions.

Early data come from surveys of people who use LSD microdoses regularly and report improvement in mental health-related symptoms or «increased general well-being.»

One of these studies analyzed data from an online survey of 98 participants who had experience with microdosing. The study’s results suggest that microdosing with psychedelics may have potential benefits for treating specific health problems, such as anxiety, depression, and chronic pain. However, it is essential to note that the study has limitations, including small sample size and the potential for self-selection bias.

There are also anecdotal reports suggesting a possible effect in enhancing creativity

 A clinical trial published in 2020 aimed to investigate the effects of low doses of LSD on mood and cognitive performance in healthy volunteers.

The study involved 24 randomly assigned participants to receive a single dose of LSD or placebo, with the amount of LSD ranging from 5 to 20 micrograms. Results showed that a low dose of LSD (5 and 20 mcg) enhances sustained attention, affects mood state in a positive direction. But it also increases confusion, and reduces the speed of information processing. 

In another study, volunteers used 6.5, 13, or 26 micrograms of LSD once a week for four weeks. The results of the study showed that participants who received microdoses of LSD reported slight changes in their subjective experience, including increased positive mood, increased attention, and enhanced sensory perception. However, these effects were subtle and did not significantly impact behavior or cognitive performance. 

So the available data suggest that small doses of LSD may have a different effect from the psychedelic effects of high dosages. But we cannot recommend or provide guidelines for its use as the number and quality of available studies are insufficient. We can highlight the following:

  • Doses above 20 micrograms may produce effects that are hardly compatible with daily activity, at least for some people.
  • Estimating such low doses from commercially available LSD can be very difficult. Scientific research uses pharmaceutical-grade LSD.
  • The appropriate frequency of use is unclear. User surveys indicate that some users take it «every day,» «every 48 hours», «once a week»… It should be borne in mind that, at least at usual doses, LSD produces pharmacological tolerance within a few days.
  •  The role of set and setting (user’s mindset and environment.) in the case of microdosing is also subject to study.
  •  It is also unclear whether microdose LSD is helpful to alleviate symptoms of illnesses (depression, anxiety…) or whether the possible effect would also benefit healthy people.

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Isotretinoin and recreational drugs

DoctorXFiles

If I take Isotretinoin, it’s safe to use LSD, Psylocibin, DMT, weed and alchool?
How often is to often to take LSD and DMT? What are harms of DMT?

Originally posted in SR 2.0 . Reviewed 20/2/22

Isotretinoin is a drug used in the treatment of some types of acne. Alcohol is the only drug strictly contraindicated with isotretinoin because of its toxic effect on the liver. All other substances listed are pharmacologically safe in combination with isotretinoin.

Some indirect data suggest that psilocybe mushrooms may also slightly increase the risk of liver problems in combination with isotretinoin. But in practice, no toxicity cases are reported, and this combination is probably safe.

Taking psychedelics is like going to Disneyworld (if you like Disney characters, of course). The first few times are extraordinary, but you will get tired and bored if you go too often. The frequency (in both cases) depends on personal preference. For some people, it’s twice a year. For others, once a month, but most people find it boring to do it every weekend. Generally, the less frequent the use, the greater the likelihood of enjoying the experience.

DMT, like other classic psychedelics, produces no effects. Harm is related to mental problems (anxiety, difficulty integrating the experience) or, very rarely, persistent mental health problems.

 

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LSD and chest pain

DoctorXFiles

Are LSD and chest pain related?

Hey Doc, i have a question about some (presumably) LSD and chest pain i took:

So i got it from a reputable SR vendor  and tried out a single 100-125 ug tab. Only experience with drugs before this (except alcohol and tobacco) is weed a single time. I ate probably both too much and the wrong things (meat) before the trip, but i haven’t read that this could cause these pains.

In fact, the experience went pretty well. However, i had for some time this persistent ache in my leftmost chest. During the trip i took notes and described it as a warm feeling like my chest muscles/heart was slowly melting down across the chest. A week later i microdosed 25 ug and had that same feeling. It was a single, short stab of pain in that area as well. Not too extreme but strong enough to worry me.

It tasted only slightly metalic, not bitter as i’ve read NBOMES do, but mostly sort of sour, and the taste lingered slightly throughout the trip.

So, I hope it was just have been panic attacks (the first time was just fuck-all overwhelming, and i accidentally swallowed the microdose after some time and thought it wouldn’t work, so that trip wasn’t entirely expected either), but i’d like to hear a qualified view on it.

Originally posted in SR 2.0 7/6/14 . Reviewed 11/2/23

It is impossible to know what has happened without knowing the content of the substance.

Chest pain is a possible symptom of a panic attack after taking psychedelics, but it is usually accompanied by psychological symptoms (anxiety, fear, etc.). Chest pain of cardiac origin tipically is «tightness radiating to the left arm» and accompains with nausea and vomiting.

In fact, LSD does not produce noticeable cardiovascular effects. A few psychedelics currently available in the market (NBOMEs, bromodragonfly, DO-X) are  active in microgram doses. There substances are sometimes counterfeits of LSD. And all these substances have considerable organic toxicity, which is absent in LSD.

LSD blotters or drops fluoresce if placed under a black light (the type of light used in some nightclubs). The technique is a bit rudimentary but it allows at least to rule out certain counterfeits. So, a Drug Checking Service is the ideal option, if available.

 

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