Neurotoxicidad de la MDMA

Comparativamente, ¿Cual es la neurotoxicidad de la MDMA en relación con las feniletilaminas psicodélicas?

Últimamente he estado leyendo mucho sobre las MDMA y fenetilaminas psicodélicas: cómo pueden estimular el metabolismo del cuerpo, inducir el sentimiento de amor y posiblemente mejorar la función cognitiva y el estado de ánimo.

A nivel personal, puedo decir que después de consumir una variedad de diferentes compuestos 2C-x en dosis más bajas, nunca he tenido efectos secundarios adversos, lo que no puedo decir de la MDMA.

2C-I, 2C-E y otros compuestos 2C-x parecen utilizar un enfoque más bien de «pago anticipado», en el que te sientes como una mierda al principio (no muy diferente a la mescalina), pero luego te sientes increíble durante el proceso. el viaje y sin ningún tipo de percance en la bajada.

¿Pueden las fenetilaminas psicodélicas causar daños similares a los que la MDMA causa a las neuronas? ¿Podrías empezar a quemarte agujeros en el cerebro si tomas fenetilaminas psicodélicas demasiadas veces, o son bastante seguras en comparación con la MDMA?

Originally posted in SR 2.0 4/2/14 . Reviewed 5/2/23

Es importante entender que las drogas no pueden clasificarse únicamente como buenas o malas; sus efectos dependen de la forma en que se utilicen.

Es un mito que las drogas pueden quemar agujeros en el cerebro, ya que sustancias como el ácido clorhídrico no se consideran drogas.

Leyendas urbanas sobre los efectos de la MDMA

La MDMA, por otro lado, ha sido objeto de cuatro décadas de intensa investigación tanto en humanos como en animales, lo que la hace mucho más segura que las feniletilaminas psicodélicas. La MDMA se ha probado en miles de personas en ensayos clínicos, mientras que la farmacología humana de 2C-B o 2C-E sólo se ha documentado en estudios anecdóticos.

El uso de feniletilaminas de la familia 2C es poco común a nivel poblacional. Sin embargo, si bien el uso de algunos miembros como 2C-I, 2C-B y 2C-E ha pasado desapercibido durante décadas, se han reportado más casos de toxicidad y efectos adversos graves de otros más nuevos como 2C-B Fly y Bromodragonfly. frecuentemente. Además de la falta de experiencia humana, muchas feniletilaminas psicodélicas son muy potentes y pequeñas diferencias en la dosis, a veces medidas en miligramos o incluso microgramos, pueden producir efectos intensos, incluida la toxicidad en los órganos.

Es cierto que las secuelas o «baja» relacionadas con el uso de MDMA son más duras para la mayoría de las personas que con 2C-X. Esto se debe tanto a las propiedades farmacológicas de cada sustancia como a la dosis, frecuencia y patrones de uso.

MDMA and psychedelic cross-tolerance

Is there MDMA and psychedelic cross-tolerance?

 I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week.

So, my question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well controlled (A1C has been in the range of 6-6.5 for the past 10 years).

Also is there any other long term health concerns other than serotonin syndrome with psychedelics? 

Originally posted in SR2.0 Forum 2/2/14 Updated 2/2/23)

There is some degree of cross-tolerance among most «classical» psychedelics, which are phenethylamines or tryptamines that interact differently with 5-HT2A serotonin receptors. Tolerance to hallucinogenic effects developed with one substance often applies to similar substances. To reset tolerance, a minimum of several weeks or a month is needed.

LSD, DMT, and the 2C-x family are considered physically safe.

Anecdotical reports  suggest cross-tolerance between LSD and psilocybin lasts for at least 7-10 days.

For those with well-controlled diabetes who take normal precautions, there are no additional risks and the risks are similar to those of non-diabetic individuals

Diabetics should take specific precautions before using psychedelics, such as setting a watch alarm to remember to eat and take insulin. The altered perception of time and self-perception of the body can make it difficult to detect hypo- or hyperglycemic episodes. Although psychedelics do not affect blood glucose levels, it’s advisable to check blood glucose levels once or twice during the experience to ensure safety



St John’s Ward interactions

I got a quick question:

I’ve started taking St. John’s Wort extract with amazing results (treating a mild – moderate depression).Do you know how long before taking MDMA I have to discontinue St. John’s in order not to get into a dangerous situation like serotonin syndrome or spoil the roll?

What about Amphetamines? Are they dangerous whilst on St. John’s (I figured no because they are not acting on serotonin that much)? Are you aware of any other drugs that might be dangerous with St. John’s?

Do just the same rules apply to St. John’s as to any «regular» SSRI in regards to drug use? I have done an extensive research on the internet but couldn’t find an answer

Originally posted in SR 2.0 7/5/23 . Reviewed 4/2/23

St. John’s Wort is a popular herbal supplement often used to help with depression and anxiety. Some people think that because it comes from a plant, it’s a more natural and healthier option. But it can interact with other drugs and medicines.

St John´s Wort acts like a monoamine oxidase inhibitor. So, theoretically, it could induce severe adverse effects in combination with drugs whose mechanism of action is related to dopamine, norepinephrine and/or serotonin liberation.

This includes MDMA, LSD, amphetamines, cocaine, psilocybin.

The use of ketamine , GHB or cannabis is probably safe .No toxicity has been reported and according the pharmacological mechanisms an interaction does not seem likely. Anyway this combinations are no recommended, as they could worsen or trigger depressive symptoms.

To be safe, it’s a good idea to stop taking St. John’s Wort for a couple of weeks before starting any other new drugs

MDMA, amphetamines and breast-feeding

Should MDMA and amphetamines be avoided during lactation? Is it strictly forbidden or risks are acceptable?

Originally posted in SR 2.0 31/10/2013. Reviewed 20/2/22

The relation between MDMA and lactation is not clear. As far as I know, there are no published studies on this particular issue. Available data on amphetamine show that «In dosages prescribed for medical indications, some evidence indicates that amphetamine might not affect nursing infants adversely.». On the other hand, data from methamphetamine show that meth is secreted to breast milk and it should be avoided.

In my opinion, it is basic to avoid use that can be harmful to third persons. A person can asume risks for himself but not for others, even less a baby. So there would be three options:

1) Wait to finish lactation and then use MDMA or amphs

2) Interrupt natural lactation (use artificial milk) and use MDMA or amphs

3) Collect enough milk for 3-4 days (using a breast-pump), keep it in the fridge and use it during the following days to MDMA or amphetamines use.