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MDMA and oxcarbazepine interaction

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Is there a pharmacological interaction between MDMA and oxcarbazepine?

At 4I years old I was recently diagnosed as being bipolar. So my psychiatrist put me on Oxcarbazepine / Trileptal.My question is: How does Oxcarbazepine affect LSD, MDMA, psilocybin? is there any interaction?  And, does it make it unsafe for me to use them?

Originally posted in SR2.0 7/2/14, Reviewed 2/2/23

Oxcarbazepine is not known to have any interactions with recreational psychedelics. However, it is essential to keep in mind that people who have bipolar disorder may be more sensitive to the adverse effects of drugs like LSD, MDMA, or psilocybin. This increased sensitivity is not due to drug interactions, but rather due to the underlying condition of bipolar disorder.

Bipolar disorder can manifest itself in different ways, such as cyclical manic and depressive phases, but this may not always be the case.

During depressive phases, the use of psychedelics may worsen mood symptoms. However, it is important to note that some individuals may become more aware of their symptoms and avoid using these substances altogether.

On the other hand, during manic phases, some people may exhibit normal behavior or have hypomanic episodes, while others may display clear signs of inappropriate behavior. As a result, it is crucial to have a thorough understanding of one’s specific case of bipolar disorder before deciding to use these substances.

In the event that an individual decides to use these substances, it is essential to be in the presence of trustworthy individuals who are familiar with the individual and can provide support.

MDMA is generally considered to be more manageable for most people, as it allows for better control over thoughts, feelings, and actions. However, it is worth noting that a depressive episode 24-48 hours after use is more commonly observed with MDMA than with psychedelics.

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MDMA and psychedelic cross-tolerance

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Is there MDMA and psychedelic cross-tolerance?

 I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week.

So, my question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well controlled (A1C has been in the range of 6-6.5 for the past 10 years).

Also is there any other long term health concerns other than serotonin syndrome with psychedelics? 

Originally posted in SR2.0 Forum 2/2/14 Updated 2/2/23)

There is some degree of cross-tolerance among most «classical» psychedelics, which are phenethylamines or tryptamines that interact differently with 5-HT2A serotonin receptors. Tolerance to hallucinogenic effects developed with one substance often applies to similar substances. To reset tolerance, a minimum of several weeks or a month is needed.

LSD, DMT, and the 2C-x family are considered physically safe.

Anecdotical reports  suggest cross-tolerance between LSD and psilocybin lasts for at least 7-10 days.

For those with well-controlled diabetes who take normal precautions, there are no additional risks and the risks are similar to those of non-diabetic individuals

Diabetics should take specific precautions before using psychedelics, such as setting a watch alarm to remember to eat and take insulin. The altered perception of time and self-perception of the body can make it difficult to detect hypo- or hyperglycemic episodes. Although psychedelics do not affect blood glucose levels, it’s advisable to check blood glucose levels once or twice during the experience to ensure safety

 

 

St John’s Ward interactions

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I got a quick question:

I’ve started taking St. John’s Wort extract with amazing results (treating a mild – moderate depression).Do you know how long before taking MDMA I have to discontinue St. John’s in order not to get into a dangerous situation like serotonin syndrome or spoil the roll?

What about Amphetamines? Are they dangerous whilst on St. John’s (I figured no because they are not acting on serotonin that much)? Are you aware of any other drugs that might be dangerous with St. John’s?

Do just the same rules apply to St. John’s as to any «regular» SSRI in regards to drug use? I have done an extensive research on the internet but couldn’t find an answer

Originally posted in SR 2.0 7/5/23 . Reviewed 4/2/23

St. John’s Wort is a popular herbal supplement often used to help with depression and anxiety. Some people think that because it comes from a plant, it’s a more natural and healthier option. But it can interact with other drugs and medicines.

St John´s Wort acts like a monoamine oxidase inhibitor. So, theoretically, it could induce severe adverse effects in combination with drugs whose mechanism of action is related to dopamine, norepinephrine and/or serotonin liberation.

This includes MDMA, LSD, amphetamines, cocaine, psilocybin.

The use of ketamine , GHB or cannabis is probably safe .No toxicity has been reported and according the pharmacological mechanisms an interaction does not seem likely. Anyway this combinations are no recommended, as they could worsen or trigger depressive symptoms.

To be safe, it’s a good idea to stop taking St. John’s Wort for a couple of weeks before starting any other new drugs

LSD and nitrous oxid combination

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I have a more specific question concerning N2O (mixed with other substances like LSD).Over the last couple of months it has become somewhat if a ritual for me to induce myself into an LSD trip once or twice a month, very often with the assistance of short nitrous oxide «flashes».Now I know the effects it creates: Next to light headedness, slight euphoria and halluzinogenic coloring, I get a strong visual and sonic «echoing». Visual in the case that it’s like you are only able to see one still picture, and after the effects of the N2O slowly wear off, more and more of your surrounding increasingly starts to move again, but in an «echoey» way.This lasts for around 1-2 minutes, as usual.The last time I did such a LSD-N2O session though, one of these echoing «flashes» lasted worryingly long… I’m guessing well over half an hour!Does anyone remember the movie Riddick, when the Lord Marshal had this ghosting effect on his body? Imagine that, but on everything that is moving in your viewing field, and at much stronger effect!During that time you begin to panic because the effect isn’t wearing off, until you settle down and consider that a) the LSD is prolonging the effect and it will slowly wear off with the drug, or b) you have caused yourself an irreversible amount of brain damage.Thankfully it did wear off and I’m feeling fine again, but obviously it made me reconsider this practise of mixing both drugs to that extent. We’re talking about 300-400ug LSD plus ten capsules of gas in a five hour time frame…I know that neither LSD nor N2O have been tested scientifically to an extent, or even combined, and that a high amount of nitrous oxide can cause brain damage and B12 deficiency.But I’m asking myself HOW dangerous this mix is, and if there have been reports of N2O effects lasting that long, and/or if the effects are «normal» and how dangerous they are…Sorry for writing down the whole story, but it genuinely scared me and I wanted you to have a detailed picture of the situation, maybe you can help me out with some insight!

Originally posted in SR2.0 5/4/14 . Reviewed 4/2/23

LSD, is a powerful psychoactive substance known for its mind-altering effects. Effects can vary widely, and this variability is wider if it is combined with any other psychoactive substance. 

LSD is generally considered to be non-neurotoxic, even at high and frequent doses. 

Long-term exposure to high doses of nitrous oxide (N2O) can lead to neurotoxicity. N2O is a potent anesthetic and can cause a decline in vitamin B12 levels, which can lead to nerve damage. Chronic exposure to N2O can also lead to other adverse effects, such as memory impairment, balance problems, and cognitive decline. However, occasional or low-dose exposure to N2O is not considered to be neurotoxic

However, it is important to be cautious when combining LSD and other substances, including N2O. While the combination of these substances may not have serious neurobiological effects, it can still trigger panic attacks or unpleasant experiences for some individuals, depending on the doses used and personal characteristics.

Tooth ache, LSD and 2C-B

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For tooth pain, would it be safe to use a topical cream such as Orajel when taking LSD & 2cb?

Originally posted in SR 2.0 4/6/22 . Reviewed 3/2/22

Topical creams and psychedelics usually do not interact with each other.

However, it is important to note that psychedelics can significantly affect pain and bodily sensations, potentially altering them, intensifying them, or even giving them a different meaning.

If you have previous experience with psychedelics, you may understand this concept.

When considering the use of psychedelics, it is important to take this factor into account. To get the most out of your experience, it is advisable to use psychedelics when you are in good physical health, if possible