LSD and chest pain

Are LSD and chest pain related?

Hey Doc, i have a question about some (presumably) LSD and chest pain i took:

So i got it from a reputable SR vendor  and tried out a single 100-125 ug tab. Only experience with drugs before this (except alcohol and tobacco) is weed a single time. I ate probably both too much and the wrong things (meat) before the trip, but i haven’t read that this could cause these pains.

In fact, the experience went pretty well. However, i had for some time this persistent ache in my leftmost chest. During the trip i took notes and described it as a warm feeling like my chest muscles/heart was slowly melting down across the chest. A week later i microdosed 25 ug and had that same feeling. It was a single, short stab of pain in that area as well. Not too extreme but strong enough to worry me.

It tasted only slightly metalic, not bitter as i’ve read NBOMES do, but mostly sort of sour, and the taste lingered slightly throughout the trip.

So, I hope it was just have been panic attacks (the first time was just fuck-all overwhelming, and i accidentally swallowed the microdose after some time and thought it wouldn’t work, so that trip wasn’t entirely expected either), but i’d like to hear a qualified view on it.

Originally posted in SR 2.0 7/6/14 . Reviewed 11/2/23

It is impossible to know what has happened without knowing the content of the substance.

Chest pain is a possible symptom of a panic attack after taking psychedelics, but it is usually accompanied by psychological symptoms (anxiety, fear, etc.). Chest pain of cardiac origin tipically is «tightness radiating to the left arm» and accompains with nausea and vomiting.

In fact, LSD does not produce noticeable cardiovascular effects. A few psychedelics currently available in the market (NBOMEs, bromodragonfly, DO-X) are  active in microgram doses. There substances are sometimes counterfeits of LSD. And all these substances have considerable organic toxicity, which is absent in LSD.

LSD blotters or drops fluoresce if placed under a black light (the type of light used in some nightclubs). The technique is a bit rudimentary but it allows at least to rule out certain counterfeits. So, a Drug Checking Service is the ideal option, if available.


MDMA / LSD and sildenafil combination

Is it safe having sildenafil with lsd or mdma in combination?

Originally posted in SR 2.0 16/4/14. Reviewed 9/2/23

There are no reported cases of severe toxicity mixing MDMA or LSD and sildelnafil. The combination is probably safe from a pharmacological point of view.

The risk of problems or adverse effects depends on dosage, timing, previous experience with both substances and personal characteristics. Some common effects of sildenafil (headache, nasal congestion) could be enhanced by psychedelic effects.

Let’s just say that when it comes to exploring the depths of sexuality and substances , it’s all about finding the right dose. 

The psychedelic effects of low to moderate doses of LSD can offer a unique perspective on sex that some people may find interesting. Too much LSD and you’ll be absorbed by a fractal  kaleidoscope of colors, completely forgetting about any naughty intention.

Something similar (though less intense) happens with MDMA. Low to medium doses can intensify and modify the qualities of sex, and a moderate dose of sildenafil can help a man maintain an erection (if that is what is intended). Increasing the dose is more likely to result in deep conversation, cuddling and cuddling (which isn’t bad either). In the latter case, sildenafil is likely to be ineffective and have mostly adverse effects.

In any case, the most dangerous combination is between PDE-5 inhibitors (Viagra, Cialis, Levitra…) and poppers. Both substances causes rapid blood flow and risks of  low blood pressure and fainting are common. In rare cases or persons with previous cardiological diseases it is possible to suffer more severe problems (heart attack, arrythmias…)

Hyperthyroidism and drugs

I’ve posted a couple times about rapid heart palpitations I’ve been getting recently. I don’t believe it’s drug related, all I’ve been doing is LSD, psilocybin and DMT.

I had been taking Adderall but cut it out when this started.I got into a free clinic and was told my problem could be hyperthyroid. That also happens to run in my family (my mother had to get the radioactive iodine treatment to kill hers).

They said my thyroid was slightly englarged (no nodules though) and I HAVE been feeling a slight tightness in my neck right over the gland (didn’t even put it together until I was at the docs office).All they did was give me a beta blocker and ask me to come back in a month. The beta blocker IS slowing my heart and lowering my BP, but it’s only addressing a symptom and not the problem, right?I know there’s no sure fire cure for hyperthyroid issues, but do you have any experience/suggestions on how to control it? I’d rather not take thyroid suppressing chems and definitely don’t want to nuke my damn thyroid.I’ve heard that bugleweed and motherwort can help lower thyroid function over time. Is there anything dietary I should/shouldnt be doing? I’ve also heard it can be due to low/high iodine levels but I wouldn’t want to start meddling with that without knowing wether my iodine is high or low.

Could applied kinesiology give me a clue? Do you even believe in that and should I?I’m staying away from all stims, be it caffiene, decongestants or uppers. I’m still using psychedelics about 1x per week and the rapid heart beat is of course more noticable and worrying while in that state. It’s becoming a real bummer on my life and my trips!Again, I don’t expect conclusive answers but anything you have to offer on hyperthyroidism is greatly appreciated!

Originally posted in SR 11/3/14 .Reviewed 6/2/13

The type of treatment that is best for you depends on factors such as your age, sex, the cause of your hyperthyroidism, the amount of thyroid hormone produced by your body, and any other medical conditions you may have.

In general, antithyroid drugs, radioactive iodine, and surgery are considered to be the most effective options. Sometimes, treatment for hyperthyroidism can lead to hypothyroidism, requiring daily hormone replacement therapy via oral administration.

However, this is not a major concern for most people and has fewer risks and complications compared to uncontrolled hyperthyroidism. The effectiveness of natural herbs or supplements is unknown.

I would advise against the use of psychedelics for your specific condition, at least until your diagnosis is clearly established. Use of ketamine is particularly contraindicated in this condition.

MDMA and oxcarbazepine interaction

Is there a pharmacological interaction between MDMA and oxcarbazepine?

At 4I years old I was recently diagnosed as being bipolar. So my psychiatrist put me on Oxcarbazepine / Trileptal.My question is: How does Oxcarbazepine affect LSD, MDMA, psilocybin? is there any interaction?  And, does it make it unsafe for me to use them?

Originally posted in SR2.0 7/2/14, Reviewed 2/2/23

Oxcarbazepine is not known to have any interactions with recreational psychedelics. However, it is essential to keep in mind that people who have bipolar disorder may be more sensitive to the adverse effects of drugs like LSD, MDMA, or psilocybin. This increased sensitivity is not due to drug interactions, but rather due to the underlying condition of bipolar disorder.

Bipolar disorder can manifest itself in different ways, such as cyclical manic and depressive phases, but this may not always be the case.

During depressive phases, the use of psychedelics may worsen mood symptoms. However, it is important to note that some individuals may become more aware of their symptoms and avoid using these substances altogether.

On the other hand, during manic phases, some people may exhibit normal behavior or have hypomanic episodes, while others may display clear signs of inappropriate behavior. As a result, it is crucial to have a thorough understanding of one’s specific case of bipolar disorder before deciding to use these substances.

In the event that an individual decides to use these substances, it is essential to be in the presence of trustworthy individuals who are familiar with the individual and can provide support.

MDMA is generally considered to be more manageable for most people, as it allows for better control over thoughts, feelings, and actions. However, it is worth noting that a depressive episode 24-48 hours after use is more commonly observed with MDMA than with psychedelics.

MDMA and psychedelic cross-tolerance

Is there MDMA and psychedelic cross-tolerance?

 I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week.

So, my question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well controlled (A1C has been in the range of 6-6.5 for the past 10 years).

Also is there any other long term health concerns other than serotonin syndrome with psychedelics? 

Originally posted in SR2.0 Forum 2/2/14 Updated 2/2/23)

There is some degree of cross-tolerance among most «classical» psychedelics, which are phenethylamines or tryptamines that interact differently with 5-HT2A serotonin receptors. Tolerance to hallucinogenic effects developed with one substance often applies to similar substances. To reset tolerance, a minimum of several weeks or a month is needed.

LSD, DMT, and the 2C-x family are considered physically safe.

Anecdotical reports  suggest cross-tolerance between LSD and psilocybin lasts for at least 7-10 days.

For those with well-controlled diabetes who take normal precautions, there are no additional risks and the risks are similar to those of non-diabetic individuals

Diabetics should take specific precautions before using psychedelics, such as setting a watch alarm to remember to eat and take insulin. The altered perception of time and self-perception of the body can make it difficult to detect hypo- or hyperglycemic episodes. Although psychedelics do not affect blood glucose levels, it’s advisable to check blood glucose levels once or twice during the experience to ensure safety