Drugs for opiates withdrawal

What are the best drugs for opiates withdrawal?

What are some of the best ways to mitigate opiate/heroin withdrawals? Besides not doing opiates/heroin of course… In the country I live in , methadone is illegal so I have to buy it in SR

Originally posted in SR 2.0 13/10/2013 . Reviewed 20/2/22

Detoxification with opioids (descending dosages of methadone, codeine or buprenorphine) is the simplest and less umconfortable way for heroin/opiate withdrawal. If, for any reason, these drugs are not used, clonidine could be an option

To minimize opioid withdrawal symptoms and signs, it’s essential to reduce the opioid dosage gradually. Tapering plans should be personalized based on the patient’s goals and concerns. The longer the duration of previous opioid therapy, the longer the taper may take. Tapers are often better tolerated if they are slower, especially following opioid use for more than a year.

Slower tapers involve a dose reduction of 5% to 20% every 4 weeks

Faster tapers decrease by 10% of the original dose per week or slower.

Clonidine acts on abdominal pain, shivering, muscular cramps and other physical symptoms but it is not very useful for anxiety and insomnia. Short time use of benzodiacepines like chlorazepate or midazolam (oral) can help.

L-acetyl-carnitine acts on pain in methadone detoxification. According to my professional experience it is useful for other opiates detoxification, too

http://www.ncbi.nlm.nih.gov/pubmed/18978503‎

General measures: good hydration, soft meals, resting…are useful, too.

These are general orientations, pattern of treatment and selection of drugs must be personalized. If you think this can help we can chat or skype

 

Tramadol for methadone withdrawal

Tramadol for methadone withdrawal

I’ve been on methadone for 1.25 Years now, and I’ve been on a steady dosage of 20mg every 24 hours (oral dose). However, I bought it illegally the entire time, as the local methadone clinics have a waiting list that aren’t worthwhile to me.

2 days ago, my «source» sold it off on me, so now I’m left to be sick for the next 6-7 days. I have access to the following pills. But I’m not quite sure if they are worthwhile for someone who is methadone sick. (I know 20mg is not much, but its not comfortable being sick from it for a week).

The pills are: Zytram XL 400mg aka Tramadol Hydrochloride 400mg

Originally posted in SR 2.0 27/10/2013. Reviewed 20/2/22

Compared to other opioids, methadone withdrawal symptoms tend to be slower to onset, longer in duration, and milder in intensity. But it can last for several weeks or even months. This is because methadone has a longer half-life than most other opioids, meaning it stays in the body longer.

Symptoms of methadone withdrawal may include nausea, vomiting, diarrhea, stomach cramps, anxiety, restlessness,  and cravings for the drug. However, unlike other opioids, methadone withdrawal symptoms tend to peak later (around 72 hours after last dose) and last longer (up to 3-4 weeks) due to its slow elimination from the body.

Tramadol is a weak μ-opioid receptor agonist, a serotonin releaser and a reuptake inhibitor of norepinephrine. It has some opioid properties but not acting as a strong opioid. At least in theory it is not a good option for avoid methadone withdrawal.

There are not availabnle studies for methadone detoxification using tramadol. There is a study comparing tramadol (200 mg/8h) and methadone (20 mg/ 8 h), for treating opioid withdrawal in 70 people. The researchers found that both drugs worked similarly well in reducing withdrawal symptoms, but the methadone group experienced more pain. 

Methadone is a medication that is used to treat opioid addiction and is listed as an essential medicine by the World Health Organization (WHO). However, its availability and accessibility vary greatly across different countries and regions.

In some countries, methadone is widely available through government-run treatment programs and healthcare facilities. For example, in Europe, methadone is a commonly used medication-assisted treatment for opioid addiction,  available through licensed clinics and providers.

In other countries, however, access to methadone is severely limited or even illegal. For example, in some parts of Asia, methadone treatment is often inaccessible due to government policies and cultural attitudes towards addiction. This can lead to increased stigma and discrimination against people who use drugs, as well as higher rates of HIV and other health problems.

The availability of methadone is also tied to broader drug policies and human rights issues. In many countries, drug policies prioritize punishment and criminalization over harm reduction and healthcare. This can lead to people who use drugs to deal with stigmatized, criminalized, and denied access to vital healthcare services.