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MDMA and psychedelic cross-tolerance

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Is there MDMA and psychedelic cross-tolerance?

 I’m having a difficult time actually getting visuals when taking LSD or the 2c family (2c-e, 2c-p, 2c-b). Only connection I can come up with is the fact that I did DMT a few days prior, but again the 2nd time I did LSD I didn’t do DMT for about a week.

So, my question is do they work on the same receptors or does the DMT effect the trip of LSD/2c family? Some things I also noticed is when I did 2c-b/LSD, I would get a cramp on my upper trapezius muscle but when I did DMT during the LSD I it would just go away. Additionally I should mention that I have type 1 diabetes which is well controlled (A1C has been in the range of 6-6.5 for the past 10 years).

Also is there any other long term health concerns other than serotonin syndrome with psychedelics? 

Originally posted in SR2.0 Forum 2/2/14 Updated 2/2/23)

There is some degree of cross-tolerance among most «classical» psychedelics, which are phenethylamines or tryptamines that interact differently with 5-HT2A serotonin receptors. Tolerance to hallucinogenic effects developed with one substance often applies to similar substances. To reset tolerance, a minimum of several weeks or a month is needed.

LSD, DMT, and the 2C-x family are considered physically safe.

Anecdotical reports  suggest cross-tolerance between LSD and psilocybin lasts for at least 7-10 days.

For those with well-controlled diabetes who take normal precautions, there are no additional risks and the risks are similar to those of non-diabetic individuals

Diabetics should take specific precautions before using psychedelics, such as setting a watch alarm to remember to eat and take insulin. The altered perception of time and self-perception of the body can make it difficult to detect hypo- or hyperglycemic episodes. Although psychedelics do not affect blood glucose levels, it’s advisable to check blood glucose levels once or twice during the experience to ensure safety

 

 

Smoking alternatives

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What method of inhalation would you advise to a person with chronic bronchitis, would it be possible to increase dosage to make up for the inability/reduced ability to absorb smoke/vapor?

Originally posted in SR 2.0 5/5/14 . Reviewed 4/2/23

Smoking is not recommended for individuals suffering from chronic bronchitis as it can exacerbate the condition. There are alternative devices that can be used, depending on the substance being inhaled into the lungs. For example, there are models of cannabis vaporizers that have been approved, tested in clinical trials, and shown to effectively deliver THC and CBD without the addition of harmful substances.

In some countries such as the United Kingdom, New Zealand, and France, there is sufficient evidence to suggest that electronic cigarettes can reduce the harm associated with nicotine use. These devices produce significantly fewer harmful substances compared to traditional smoking of tobacco.

However, for other substances such as crack, heroin, and methamphetamine, there are no alternatives or these alternatives have not been evaluated. The level of contamination of these substances is also a crucial factor to consider.

  • In summary, advantages of these devices are:
  • Lower Health Risks: Vaporizing avoids the harmful by-products of smoking such as tar and carbon monoxide, which can cause serious health problems over time.
  • Reduced Exposure to Toxins: The heating process in a vaporizer releases the active ingredients without burning plant material, reducing the exposure to toxic chemicals that may be present in the smoke.
  • Improved Flavor: Vaporizing can provide a better and purer flavor experience compared to smoking, as it eliminates the harshness that can come with smoking.
  • Discreetness: Vaporizers are typically quieter and produce less odor than smoking, making it a more discreet option for consumption.
  • Increased Efficiency: Vaporizing is generally considered more efficient than smoking, as it allows the user to consume less material to achieve the desired effects.
  • Cost-effective: Over time, vaporizing can be more cost-effective than smoking, as vaporizers are reusable and require less plant material to achieve the same results as smoking.

Cocaine snorting technique

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What is the correct cocaine snorting technique?

I wanted to ask if I should be worried about itchy nose after using cocaine.

At the time of snorting I had some nose bleed. It stopped fairly quickly within half an hour. Since then only once I had some blood coming out on a tissue but just once, two days after my first cocaine intake. Then, 5 days after the first intake I snorted again the same shit. But this time I didn’t have any nose bleeding.

However, since then I have felt my nose fragile and sort of itchy. In the last few days it has become increasingly itchy and I would say it even hurts a tiny bit. No bleeding, however. I have also been sneezing a lot and having runny nose for the last two days, sort of flu symptoms.

Timespan:
1st snort 14th of Feb (with bleeding). Second bleeding 16 Feb.
2nd snort 18th Feb (no bleeding)
27th Feb until now – increased itchy-ness and flu sympthoms like sneezing, feeling down, runny nose (not sure if actual flu or just the nose)

Unfortunately, it wasn’t the purest of cocaine… Do you think I should be worried?

Originally posted in SR 2.0 7/6/14 . Reviewed 4/2/23

It is uncommon for snorting occasional moderate amounts of cocaine to result in severe-chronic health problems.  To help recover, it is recommended to wash your nostrils with a warm saline solution twice a day for 7 to 10 days using a syringe.

So, in terms of the snorting technique, you should crush the substance into a fine powder before sniffing it. To avoid irritation in the same nostril, it is recommended both for snorting.

When using a snorting straw, it is important to direct the straw towards the lateral part of the nasal turbinates instead of the nasal septum. This is because the nasal turbinates have better blood flow and therefore better absorption.

Some symptoms that may indicate a complication and suggest medical evaluation are:

  • persistent bleeding, continuous and persistent nasal congestion,
  • thick white and foul-smelling nasal discharge
  • intense pain in your cheeks or forehead
  • fever

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Cocaine and nose bleeding

DoctorXFiles

I wanted to ask if I should be worried about itchy nose after using cocaine.

At the time of snorting I had some nose bleed. It stopped fairly quickly within half an hour. Since then only once I had some blood coming out on a tissue but just once, two days after my first cocaine intake. Then, 5 days after the first intake I snorted again the same shit. This time I didn’t have any nose bleeding. However, since then I have felt my nose fragile and sort of itchy. In the last few days it has become increasingly itchy and I would say it even hurts a tiny bit. No bleeding, however. I have also been sneezing a lot and having runny nose for the last two days, sort of flu symptoms.

Timespan:
1st snort 14th of Feb (with bleeding). Second bleeding 16 Feb.
2nd snort 18th Feb (no bleeding)
27th Feb until now – increased itchy-ness and flu sympthoms like sneezing, feeling down, runny nose (not sure if actual flu or just the nose)

Unfortunately, it wasn’t the purest of cocaine… Do you think I should be worried?

Originally posted in SR 2.0 7/6/14 . Reviewed 4/2/23

It is uncommon for snorting occasional moderate amounts of cocaine to result in severe-chronic health problems.  To help recover, it is recommended to wash your nostrils with a warm saline solution twice a day for 7 to 10 days using a syringe.

In terms of the snorting technique, it is advisable to crush the substance into a fine powder before sniffing it. To avoid irritation in one nostril, it is recommended to alternate nostrils for snorting. When using a snorting straw, it is important to direct the straw towards the lateral part of the nasal turbinates instead of the nasal septum. This is because the nasal turbinates have better blood flow and therefore better absorption.

Some symptoms that may indicate a complication and suggest medical evaluation are:

  • persistent bleeding, continuous and persistent nasal congestion,
  • thick white and foul-smelling nasal discharge
  • intense pain in your cheeks or forehead
  • fever

St John’s Ward interactions

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I got a quick question:

I’ve started taking St. John’s Wort extract with amazing results (treating a mild – moderate depression).Do you know how long before taking MDMA I have to discontinue St. John’s in order not to get into a dangerous situation like serotonin syndrome or spoil the roll?

What about Amphetamines? Are they dangerous whilst on St. John’s (I figured no because they are not acting on serotonin that much)? Are you aware of any other drugs that might be dangerous with St. John’s?

Do just the same rules apply to St. John’s as to any «regular» SSRI in regards to drug use? I have done an extensive research on the internet but couldn’t find an answer

Originally posted in SR 2.0 7/5/23 . Reviewed 4/2/23

St. John’s Wort is a popular herbal supplement often used to help with depression and anxiety. Some people think that because it comes from a plant, it’s a more natural and healthier option. But it can interact with other drugs and medicines.

St John´s Wort acts like a monoamine oxidase inhibitor. So, theoretically, it could induce severe adverse effects in combination with drugs whose mechanism of action is related to dopamine, norepinephrine and/or serotonin liberation.

This includes MDMA, LSD, amphetamines, cocaine, psilocybin.

The use of ketamine , GHB or cannabis is probably safe .No toxicity has been reported and according the pharmacological mechanisms an interaction does not seem likely. Anyway this combinations are no recommended, as they could worsen or trigger depressive symptoms.

To be safe, it’s a good idea to stop taking St. John’s Wort for a couple of weeks before starting any other new drugs