Combining D-amphetamine  and methylphenidate: Effects on Amphetamine Neurotoxicity

I am prescribed D-amphetamine (Dexedrine® ) and methylphenidate (Ritalin®).
So…would it be a good idea to combine the two drugs to avoid effects on amphetamine neurotoxicity?

Originally posted in SR 2.0 13/10/2013 . Reviewed 20/2/22

Some animal models have shown neurotoxic effects of dextroamphetamine at very high doses. However, the dosages prescribed for humans are typically below the neurotoxic threshold. The neurotoxic potential of methylphenidate, an amphetamine derivative, is even lower and considered insignificant. Therefore, there is no need for concern about neurotoxicity when taking these drugs at the prescribed dosage via oral route.

So, combining D-amphetamine (Dexedrine® ) and methylphenidate (Ritalin®) would not have any effect on neurotoxicity as it is unlikely to occur at therapeutic doses. However, combining the two drugs can increase the risk of adverse effects, and therefore, it is not recommended.