Xanax (alprazolam) or any other short half-life benzodiazepine may be an option to resolve a panic attack in an acute situation, and the fact that your friend suffers from Crohn’s disease is not relevant in this regard.

However, there are some additional considerations. You must be absolutely sure that your friend’s problem is indeed a «panic attack». The effects and risks of 25i_NBOMe are unpredictable and, in case of doubt, a medical evaluation is recommended to rule out possible serious organic complications.

The duration of the alleged «panic attack» is important in this regard as it does not seem a likely diagnosis if the symptoms last more than a few hours.

I do not believe that there is a direct link between psychedelics and Crohn’s disease, although it is true that anxiety disorders are more frequent in these patients.

Benzodiazepines such as alprazolam should never be used as the sole long-term pharmacological treatment for anxiety disorders. There are much safer and more effective pharmacological options.