Oxycodone, benzos and alcohol risks

How much Xanax and Oxycontin would be fatal when consumed together with alcohol and how much alcohol would cause problems? I know that drinking increases it greatly but I want to know if I can at least have a few, or does it all depend on height and weight?

Originally posted in SR 2.0 . Reviewed 12/2/23

Benzodiazepines, alcohol or oxycodone are rarely fatal in overdose because they do not produce respiratory depression (or do so in extraordinarily high doses). But the risk increases when combining two substances, and even more mixing all three

It is very difficult to know exactly what is the dose above which the risk is elevated. They are drugs with different pharmacological properties. Weight, sex, age and tolerance are also factors to be considered.  Low-dose combinations probably does not  increase the risk of death, but uncomfortable adverse effects (such as amnesia) are very likely to occur.

In a series of 575 deaths attributed to oxycodone in Sweden between 2006-2018, the most commonly detected drugs were benzodiazepines (70%) and alcohol (50%). Another similar study found the same association between the three substances, with alprazolam (Xanax, Trankimazin). In this series, these appeared as   as the benzodiazepine most associated with oxycodone poisoning deaths.

There are anecdoticar reports of cases of death caused by  the combination of oxycodone and clonazepam at high doses 



Expiry of benzodiacepines

Hey DoctorX,
What is the best method of storing pills (Xanax, Valium, ect)..?
Also how long does it take for them to start loosing thier potency..?

Originally posted in SR 2.0 9/6/14 . Reviewed 11/2/23

Benzodiacepines can be stored in «normal» conditions. There is no need for frigdes or special containers (unless you live in a ecuatorial or tropical country).

In a environment of 10-25ºC, no extreme humidity and no direct sunlight, they will keep their quality for several years. A noticeable lose of potency will occur 5-10 years after production.