LSD tolerance and microdosing

Hello, I have a question about LSD tolerance and microdosing. Yes.  I know is unknown territory but please let me know if this is a wrong line of thought.

Average trip 200ug needs at least 14 days for you to restore tolerance. But with less amount wouldn’t you also need less time for that?

So if I take 10ug that’s 5% then I would need only 5% of the restoring time, that is 0.75 days. According to this logic only 1 day after that dosage will be more than plenty to recuperate and don’t build tolerance.

And if you take even lower amount, let’s say 5ug or 2.5% that’s 0.375 days of recovery time. So if you take it at the morning, for example 8:00 AM, next morning at the same hour you will be more than recovered. So you could take 5ug all week?. This will require testing and I guess is variable to each individual.

I’m very interested in this and help is much appreciated.

Originally posted in SR 2.0 13/10/2013. Reviewed 20/2/22

To develop tolerance to LSD, a minimum dosage and frequency of administration are necessary. Tolerance depends on the chemical characteristics and metabolism of each drug. Also, to develop tolerance it is neccesary a minimun dosage and frequency of administration.

Minimum psychoactive dosage of LSD is 25 μg (micrograms, 1/1000 mg). Most people achieve full psychedelic effects with 100-200 μg.

Tolerance to LSD develops quickly (for most people it is very difficult to use LSD 2 or 3 consecutive days) and also disappears quickly. Studies show that tolerance dissapears tipically 4 days after last administration

Although reducing dosages theoretically reduces tolerance time, dosages lower than 20-30 mg have virtually no psychological effects. And daily administration of very low dosages could still affect tolerance development neurochemically.

The linear relationship between dose and tolerance is likely true within the full dose range of 75-200 μg. But this is less clear at lower doses.

The problem with microdoses is the lack of established guidelines and appropriate doses. According to different surveys, microdose users take between 5 and 20 mg. Some people do it daily, others twice a week, and others once a week.

However, there are not enough clinical trials to determine the most appropriate regimen that does not produce tolerance or psychedelic effects.

It is also unclear what the exact effect of microdoses is and which group of patients or healthy individuals can benefit from this use.

Given that this is a highly active field of research, more exact data is likely to emerge in the near future.